Mayim Bialik has hinted she's done with acting after Disney "cancelled" plans for a Blossom reboot.

The former Big Bang Theory actress - who played the title role of Blossom Russo in the sitcom from 1991 to 1995 - and creator Don Reo were keen to revive the show, but needed Disney's permission to bring the idea to life.

In a lengthy essay on her Substack, Mayim wrote: "We approached Disney as I was on the cusp of starting Call Me Kat; and was working on Jeopardy! and we simply did not have the time to develop the show but tried to lock it in quickly.

"Time ran out and I did three seasons of Call Me Kat, 2 seasons as co-host of Jeopardy! and when both of those ended, Don and I could not let the possibility of revisiting Blossom go."

The 49-year-old star insisted Disney "seemed to love it", and the duo "felt certain this was moving forward" after meeting with the studio.

Following mergers and changes in the TV industry, Mayim and Don re-pitched the plan to a new team at Disney.

She added: "Unfortunately, and for no particularly reason, we were told 'no.' "

The pair then asked if they could look into obtaining the rights themselves and try to shop the idea to other studios, in a bid to "let the market decide if audiences might want to see these characters all these years later".

Unfortunately, she has claimed Disney refused to hand over the rights to the show.

She continued: "We will likely never know (unless Disney or 20th Century Studios reads my Substack and feels compelled to chime in and comment) why they would not let us bring these beautiful stories to people who love 90s nostalgia and who have a special place in their hearts for Blossom."

Meanwhile, Mayim admitted that Blossom Russo as a character she "wants to play more than any other".

Now, she said: "My desire to continue to pursue on-camera roles as waned."

She insisted she does not take her career "for granted", and she is grateful for the "incredible" roles she's enjoyed to date.

However, she is "certain Disney got this wrong", even if "it is possible no one wants a Blossom reboot".

She said: "The sun is gonna surely shine. Maybe not the way Don and I intended, but this door closed.

"While we didn't want it to, we are powerless over every aspect of it except what we know to be true: we loved this possibility with all that we have and we are so so sorry we couldn't get it to happen."