Sam Farmer's Week 6 NFL picks

Sam Farmer, Los Angeles Times on Oct 9, 2025

Published in Football

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Los Angeles Times NFL writer Sam Farmer examines the matchups and makes his predictions for Week 6 of the NFL season.

All lines and over/under numbers are according to FanDuel Sportsbook.

Last week, Farmer posted a 7-7 (.500) record. Through the first five weeks of the season, he is 51-27 (.654).

Using point spreads with the scores Farmer predicted, his record against the spread in Week 5 would have been 7-7 (.500). For the season, his record against the spread is 40-38 (.513).

All times are Pacific and TV reflects broadcasts in the Los Angeles area. The Vikings and Texans are off this week.

Eagles (4-1) at Giants (1-4)

Thursday, 5:15 p.m.

Line: Eagles by 7 1/2. O/U: 40 1/2.

The Eagles are too talented and well-coached to collapse despite offensive struggles and missing defensive leadership. The Giants are coming off a game in which they had five consecutive turnovers.

Pick: Eagles 24, Giants 20

Broncos (3-2) vs. Jets (0-5)

Sunday, 6:30 a.m.

Line: Denver by 7. O/U: 43 1/2.

Denver is gaining momentum under Sean Payton, with a defense that can overwhelm opponents. The Jets can't protect Justin Fields, who will make some plays but will be sacked a ton.

Pick: Broncos 27, Jets 14

Rams (3-2) at Ravens (1-4)

Sunday, 10 a.m.

Line: Rams by 7 1/2. O/U: 44 1/2.

The Rams are catching the Ravens at a good time. Baltimore's offense is in disarray and its defense is ravaged by injuries. The Rams cruise with a balanced attack and experienced receivers.

Pick: Rams 31, Ravens 13

Chargers (3-2) at Dolphins (1-4)

Sunday, 10 a.m.

Line: Chargers by 4 1/2. O/U: 43 1/2.

Injuries and mistakes continue to plague the Chargers, so this is a real test for Jim Harbaugh. Miami is too up and down, and there's an opening for the Chargers to get back on track.

Pick: Chargers 24, Dolphins 20

Cardinals (2-3) at Colts (4-1)

Sunday, 10 a.m.

Line: Colts by 6 1/2. O/U: 47 1/2.

The Colts are emerging as a legitimate team with solid quarterback play, a strong defense and good coaching. Arizona plays hard but misses key playmakers such as James Conner.

Pick: Colts 24, Cardinals 18

Patriots (3-2) at Saints (1-4)

Sunday, 10 a.m.

Line: Patriots by 3 1/2. O/U: 45 1/2.

Mike Vrabel sure knows how to coach, and Drake Maye is rounding into an outstanding quarterback. The Saints are coming off a win, but the Giants totally imploded.

Pick: Patriots 27, Saints 17

Browns (1-4) at Steelers (3-1)

Sunday, 10 a.m.

Line: Steelers by 5 1/2. O/U: 38 1/2.

This one should be close thanks to Cleveland's stifling defense. Still, Aaron Rodgers gets the nod over Dillon Gabriel, plus Pittsburgh is at home.

Pick: Steelers 20, Browns 17

Cowboys (2-2-1) at Panthers (2-3)

Sunday, 10 a.m.

Line: Cowboys by 3 1/2. O/U: 49 1/2.

The Cowboys' offense looks elite again and their defense is tightening up. Carolina fights hard and makes it interesting for a while but lacks the firepower to keep up.

Pick: Cowboys 28, Panthers 20

Seahawks (3-2) at Jaguars (4-1)

Sunday, 10 a.m.

Line: Jaguars by 1 1/2. O/U: 46 1/2.

Seattle has some good young receivers and should settle into some consistency. The Jaguars keep this one close at home but the Seahawks pull away down the stretch.

Pick: Seahawks 27, Jaguars 23

Titans (1-4) at Raiders (1-4)

Sunday, 1:05 p.m.

Line: Raiders by 5 1/2. O/U: 41 1/2.

The Raiders might be mediocre, but they're better than the Titans. Cam Ward can flash with some impressive plays, but he isn't consistent enough to overcome the Las Vegas defense.

Pick: Raiders 24, Titans 20

Bengals (2-3) at Packers (2-1-1)

Sunday, 1:25 p.m.

Line: Packers by 14 1/2. O/U: 44 1/2.

The Bengals have lost three in a row, and finally got back to scoring a bit last week. That's not enough against a Packers front that's physical and rested.

Pick: Packers 30, Bengals 17

49ers (4-1) at Buccaneers (4-1)

Sunday, 1:25 p.m.

Line: Buccaneers by 3. O/U: 47 1/2.

The 49ers are rested after beating the Rams and are getting healthier. Tampa Bay has had injuries, too, and some young replacements have stepped up.

Pick: Buccaneers 28, 49ers 23

Lions (4-1) at Chiefs (2-3)

Sunday, 5:20 p.m.

Line: Chiefs by 2 1/2. O/U: 52 1/2.

The Chiefs have some lingering problems and that creates an opening for a Lions team that can score in so many ways. Patrick Mahomes keeps this close.

Pick: Lions 30, Chiefs 27

Bills (4-1) at Falcons (2-2)

Monday, 4:15 p.m.

Line: Bills by 4 1/2. O/U: 48 1/2.

The Bills bounce back after a dispiriting loss to the Patriots, with Josh Allen leading the way. The Falcons can run the ball, and will in this one, but won't keep pace on the scoreboard.

Pick: Bills 27, Falcons 23

Bears (2-2) at Commanders (3-2)

Monday, 5:15 p.m.

Line: Commanders by 4 1/2. O/U: 49 1/2.

Even when he's banged up, Jayden Daniels is a problem with his arm and feet. Washington's defense is improving. Chicago has young playmakers, but turnovers decide this one.

Pick: Commanders 28, Bears 24